Protein Details: Glutamate receptor ionotropic; NMDA 3B

Protein ID

ICDB_Pro_1325

Protein Name

Glutamate receptor ionotropic; NMDA 3B

Gene Name

Grin3b

Organism

Rattus norvegicus (Rat)

Length

1002 amino acids

AlphaFoldDB

AF-Q8VHN2-F1-model_v4.pdb

Function

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance; low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

Sequence

MESVRTLWLSVALALAVGSRVVRGHPQPCRVPTRAGASVRLAALLPRAPAARARVLAALATPAPRLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVASIAFPEARPELRLLQFLAAATETPVVSVLRREVRTALGAPTPFHLQLDWASPLETILDVLVSLVRAHAWEDIALVLCRVRDPGSLVTLWTNHASQAPKFVLDLSRLDSRNDSLRAGLALLGALEGGGTPVPAAVLLGCSTARAHEVLEAAPPGPQWLLGTPLPAEALPTTGLPPGVLALGETEQHSLEAVVHDMVELVAQALSSMALVHPERALLPAVVNCDDLKTGGSEATGRTLARFLGNTSFQGRTGAVWVTGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEGQQERAEQERSGPKDELPATDGAGRWRRVRRAVERERRVRFLLEPGEAGGDRPWLCSNGPGLQAELRELELRIEAARERLRSALLRRGELRALLGDGTRLRPLRLLHAAPAES

PDB Structures

2RCA 2RCB

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in the hippocampus; the corpus callosum; in the facial and trigeminal nuclei of the brainstem and the ventral horn of the spinal cord

DOI ID

10.1038/nature715; 10.1006/geno.2001.6666

RefSeq

NP_579842.2